PRME
Prime Medicine, Inc. · Healthcare · Biotechnology
Last
$4.63
+$0.25 (+5.59%) 4:00 PM ET
After hours $4.61 −$0.02 (−0.36%) 6:15 PM ET
Prev close $4.38
Open $4.25
Day high $4.63
Day low $4.25
Volume 5,647,769
Avg vol 2,962,887
Mkt cap
$833.96M
P/E ratio
-3.21
FY Revenue
$5.98M
EPS
-1.44
Gross Margin
100.00%
Sector
Healthcare
AI report sections
PRME
Prime Medicine, Inc.
Prime Medicine shows firm upward price momentum over the past 1–6 months with the stock trading well above key moving averages, supported by multiple bullish technical signals and elevated volume. At the same time, fundamentals remain characterized by very small revenue, large operating losses, and deeply negative free cash flow, while valuation multiples on sales and book value appear high for a loss-making issuer. Short interest is elevated with a double‑digit percentage of shares sold short and a high days‑to‑cover figure, indicating notable positioning risk around sentiment shifts.
AI summarized at 5:07 PM ET, 2026-03-01
AI summary scores
INTRADAY: 68 SWING: 72 LONG: 33
Volume vs average
Intraday (cumulative)
+130% (Above avg)
Vol/Avg: 2.30×
RSI
65.75 (Strong)
Strong (60–70)
MACD momentum
Intraday
+0.00 (Strong)
MACD: 0.03 Signal: 0.03
Short-Term
+0.10 (Strong)
MACD: 0.01 Signal: -0.09
Long-Term
+0.05 (Strong)
MACD: -0.03 Signal: -0.08
Intraday trend score 89.54

Latest news

PRME 12 articles Positive: 10 Neutral: 2 Negative: 0
Neutral GlobeNewswire Inc. • Prime Medicine, Inc.
Prime Medicine to Participate in Upcoming Investor Conferences

Prime Medicine announced that company management will participate in three upcoming healthcare and biotech conferences in March 2026, including fireside chats at the TD Cowen Health Care Conference and Citizens Life Sciences Conference, as well as 1x1 meetings at the Jefferies Biotech on the Beach Summit. Live webcasts of the fireside chats will be available on the company's website.

PRME gene editing Prime Editing platform genetic therapies biotechnology clinical development investor conference liver disease
Sentiment note

The announcement is routine corporate communication regarding conference participation. While it demonstrates active investor engagement and continued advancement of their Prime Editing platform across multiple therapeutic areas, the news itself is procedural in nature without material updates on clinical progress, regulatory milestones, or financial performance.

Positive Benzinga • Prnewswire
Gene Therapy: 5 Biotech Stocks Chasing the $36B Prize

The gene therapy market is projected to reach $36.55 billion by 2032, with the FDA approving three transformative cell therapies in December. Five biotech companies are advancing therapies across diabetes, sickle cell disease, cardiovascular disease, liver disease, and chronic granulomatous disease, with recent clinical data demonstrating significant efficacy and safety profiles.

AVAI VRTX CRSP PRME gene therapy cell therapy CRISPR clinical trials
Sentiment note

Published first-in-human Phase 1/2 data in New England Journal of Medicine for PM359 treating chronic granulomatous disease, demonstrating safety and efficacy of Prime Editing technology. Both patients exceeded clinical benefit threshold with no clinically significant adverse events.

Positive GlobeNewswire Inc. • Prime Medicine, Inc.
Prime Medicine Announces The New England Journal of Medicine Publication of PM359 Clinical Data for the Treatment of Chronic Granulomatous Disease

Prime Medicine published Phase 1/2 clinical data for PM359, an investigational gene therapy for chronic granulomatous disease, demonstrating safety and early clinical efficacy in two patients with promising results in neutrophil restoration and disease symptom improvement.

PRME gene editing prime editing chronic granulomatous disease clinical trial hematopoietic stem cells
Sentiment note

Reported successful first-in-human clinical trial results with positive patient outcomes, demonstrated safety of their prime editing technology, and showed potential for treating genetic diseases

Positive GlobeNewswire Inc. • Prime Medicine, Inc.
Prime Medicine Reports Third Quarter 2025 Financial Results and Provides Business Updates

Prime Medicine reported Q3 2025 financial results, highlighting progress in genetic therapies for Wilson's Disease and Alpha-1 Antitrypsin Deficiency, with plans to file IND/CTA applications in 2026-2027 and new preclinical data to be presented at AASLD.

PRME BMY CELGR Prime Editing genetic therapy Wilson's Disease Alpha-1 Antitrypsin Deficiency gene editing
Sentiment note

Company showed progress in pipeline development, nominated new development candidates, strengthened leadership, maintained financial runway into 2027, and presented promising preclinical data

Neutral The Motley Fool • Jesterai
PRME Revenue Misses by 73%

Prime Medicine reported Q2 2025 earnings with a net loss of $52.6 million, below analyst estimates. The company demonstrated clinical proof-of-concept for Prime Editing in chronic granulomatous disease and extended its cash runway into 2027 through strategic restructuring and funding.

PRME BMY CELGR gene editing genetic medicine clinical trials earnings report biotechnology
Sentiment note

Mixed financial performance with reduced net loss, successful clinical proof-of-concept, secured additional funding, but still reporting operating losses and below analyst revenue expectations

Positive GlobeNewswire Inc. • Gregory Dearborn
Prime Medicine Announces Pricing of Public Offering

Prime Medicine is conducting a public offering of 38 million shares at $3.30 per share, expecting to raise approximately $125.4 million. The Cystic Fibrosis Foundation will purchase 1,818,181 shares, and the offering is expected to close on August 1, 2025.

PRME public offering stock biotechnology gene editing funding
Sentiment note

The company is raising significant capital through a public stock offering, indicating growth potential and investor interest in their gene editing technology

Positive The Motley Fool • Johnny Rice
Why Prime Medicine Stock Is Soaring Today

Prime Medicine, a clinical-stage biotech company, announced a new preclinical program targeting alpha-1 antitrypsin deficiency, a genetic disorder affecting lung and liver function. Investors reacted positively to the company's plans to file an Investigational New Drug Application by mid-2026, but the development risks associated with clinical-stage biotechs remain.

PRME Prime Medicine gene-editing alpha-1 antitrypsin deficiency clinical-stage biotech
Sentiment note

The company announced a promising new preclinical program targeting a serious genetic disorder, which generated positive investor reaction and a stock price surge.

Positive GlobeNewswire Inc. • N/A
Prime Medicine Unveils Program for the Treatment of Alpha-1 Antitrypsin Deficiency (AATD)

Prime Medicine announced a preclinical program for the treatment of alpha-1 antitrypsin deficiency (AATD), a genetic disorder. The program leverages Prime Medicine's proprietary Prime Editing technology and is expected to file an IND/CTA in mid-2026.

PRME Prime Editing AATD Genetic Disorder Preclinical Program
Sentiment note

The article highlights Prime Medicine's progress in developing a preclinical program for AATD using its Prime Editing technology, which has shown promising results in restoring the disease-causing mutation. The company expects to file an IND/CTA in mid-2026, indicating advancement of the program.

Positive GlobeNewswire Inc. • Prime Medicine, Inc.
Prime Medicine Reports Third Quarter 2024 Financial Results and Provides Business Updates

Prime Medicine reported progress in its Wilson's Disease program, including in vivo data demonstrating efficient correction of disease-causing mutations. The company also announced a strategic collaboration with Bristol Myers Squibb for ex vivo T-cell therapies and expects to report initial data from its Phase 1/2 trial of PM359 for p47phox CGD in 2025.

PRME BMY CELGR Wilson's Disease Prime Editing Lipid Nanoparticle Chronic Granulomatous Disease T-cell Therapy
Sentiment note

The article highlights several positive developments for Prime Medicine, including progress in its Wilson's Disease program, a strategic collaboration with Bristol Myers Squibb, and the expected initiation of a Phase 1/2 trial for its PM359 program.

Positive GlobeNewswire Inc. • N/A
Prime Medicine to Participate in Upcoming Investor Conferences

Prime Medicine, a biotechnology company, announced that it will participate in several upcoming healthcare conferences, including the Guggenheim Healthcare Innovation Conference, Stifel 2024 Healthcare Conference, and Jefferies London Healthcare Conference. The company is focused on developing one-time curative genetic therapies using its proprietary Prime Editing platform.

PRME Prime Medicine biotechnology genetic therapies conferences
Sentiment note

The article highlights Prime Medicine's participation in upcoming healthcare conferences, which suggests the company is actively engaged in promoting its technology and pipeline. The company's focus on developing one-time curative genetic therapies using its proprietary platform also indicates a positive outlook for the company's future prospects.

Positive The Motley Fool • George Budwell
Why I Keep Buying These 14 Incredible Growth Stocks

This article discusses a diverse set of growth stocks in various industries, including AI, space, biotech, and emerging technologies. The author highlights the potential rewards and risks of investing in individual growth stocks, and provides an overview of 14 stocks in his tax-advantaged portfolios.

ACHR ACHR.WS ASPN CRSP growth stocks AI space biotech
Sentiment note

The article states that Prime Medicine's stock has fallen 57.7% year to date, but Wall Street projections suggest a 269% upside potential, highlighting the company's innovative gene-editing technology and broad therapeutic potential.

Positive The Motley Fool • Eric Volkman
Why Prime Medicine Stock Soared Nearly 12% Higher on Monday

Prime Medicine, a gene-editing company, announced a strategic research collaboration and license agreement with Bristol Myers Squibb to develop reagents for T-cell therapies. This news sent Prime Medicine's share price up nearly 12%, outperforming the S&P 500's 0.4% gain.

PRME BMY CELGR Prime Medicine Bristol Myers Squibb gene-editing T-cell therapies
Sentiment note

The article reports that Prime Medicine's share price increased by almost 12% on the news of the collaboration with Bristol Myers Squibb, indicating a positive sentiment towards the company.

News and sentiment labels describe article tone and are provided for research purposes only. They are not trading recommendations or forecasts.
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