OPK
OPKO Health, Inc. · Healthcare · Diagnostics & Research
Last
$1.21
+$0.01 (+0.83%) 4:00 PM ET
After hours $1.21 $0.00 (0.00%) 4:27 AM ET
Prev close $1.20
Open $1.19
Day high $1.26
Day low $1.19
Volume 3,756,802
Avg vol 2,865,648
Mkt cap
$921.24M
P/E ratio
-4.03
FY Revenue
$606.88M
EPS
-0.30
Gross Margin
33.93%
Sector
Healthcare
AI report sections
OPK
OPKO Health, Inc.
Opko Health Inc. shows short-term technical momentum with price above key moving averages and recent bullish pattern signals, while medium-term returns remain uneven. Fundamentally, the company operates with negative margins, loss-making operations, and materially negative free cash flow despite a sizable revenue base. The balance sheet and liquidity metrics appear solid relative to debt levels, but the combination of persistent losses and cash burn frames a cautious longer-horizon risk profile.
AI summarized at 12:21 AM ET, 2026-01-22
AI summary scores
INTRADAY: 63 SWING: 55 LONG: 34
Volume vs average
Intraday (cumulative)
+122% (Above avg)
Vol/Avg: 2.22×
RSI
42.93 (Neutral)
Neutral (40–60)
MACD momentum
Intraday
-0.00 (Weak)
MACD: -0.01 Signal: -0.00
Short-Term
-0.00 (Weak)
MACD: -0.03 Signal: -0.03
Long-Term
-0.01 (Weak)
MACD: -0.04 Signal: -0.04
Intraday trend score 57.81

Latest news

OPK 12 articles Positive: 10 Neutral: 2 Negative: 0
Positive GlobeNewswire Inc. • Na
OPKO Health to Report Fourth Quarter 2025 Financial Results on February 26

OPKO Health will report its financial results for Q4 and full year 2025 on February 26, 2026, followed by a conference call. The company has also expanded its partnership with Entera Bio to advance an oral long-acting PTH tablet for hypoparathyroidism treatment, marking the third successful program combining Entera's N-Tab platform with OPKO's protein chemistry capabilities.

OPK ENTX OPKO Health financial results Q4 2025 Entera Bio partnership expansion oral PTH tablet
Sentiment note

The company is expanding a successful partnership with Entera Bio for a third program, demonstrating continued innovation and development progress in their pipeline. The acceleration of the program indicates confidence in its potential.

Positive GlobeNewswire Inc. • Opko Health, Inc. And Entera Bio Ltd.
OPKO Health and Entera Bio Expand Partnership to Advance First-in-Class Oral Long Acting PTH Tablet for Patients with Hypoparathyroidism

OPKO Health and Entera Bio have expanded their collaboration to develop the first oral long-acting PTH analog for hypoparathyroidism treatment, aiming to file an IND application in late 2026. The companies will maintain equal 50/50 ownership and cost-sharing for this program. Additionally, they are advancing oral oxyntomodulin (dual GLP-1/glucagon analog) with Phase 1 injectable data expected by end of 2026. Steve Rubin from OPKO has joined Entera's board.

OPK ENTX oral PTH analog hypoparathyroidism N-Tab platform oxyntomodulin GLP-1/glucagon IND application
Sentiment note

Expansion of successful collaboration with favorable preclinical data, acceleration of development timeline, and advancement of multiple promising programs (oral LA-PTH and oral OXM) demonstrate strong pipeline progress and strategic positioning in peptide therapeutics.

Neutral GlobeNewswire Inc. • Miranda Toledano
Entera Bio to Participate in the 8th Annual Evercore ISI Healthcare Conference

Entera Bio's CEO will participate in the Evercore ISI Healthcare Conference, highlighting the company's progress in developing oral peptide therapies for conditions like osteoporosis and hypoparathyroidism.

ENTX OPK oral peptide osteoporosis hypoparathyroidism clinical trials bone density
Sentiment note

Mentioned as a collaboration partner for developing an oral GLP-2 peptide, with no specific positive or negative details provided

Positive Benzinga • David Phipps
NextPlat Issues CEO Shareholder Update Letter

NextPlat Corp provides an update on its strategic progress across healthcare services, communications, and e-commerce channels, highlighting cost reduction efforts, new contracts, and technology investments aimed at driving growth and profitability.

NXPL NXPLW OPK GSAT healthcare e-commerce cost reduction technology
Sentiment note

Expanding e-commerce partnership with NextPlat for health product distribution in China, with approved higher import volumes

Neutral The Motley Fool • Jesterai
Entera Bio Beats Q2 EPS Estimates

Entera Bio reported better-than-expected Q2 2025 earnings with a GAAP EPS of $0.06, secured FDA regulatory concurrence for EB613's Phase 3 trial, and maintained a strong cash position of $18.8 million to support operations through mid-Q3 2026.

ENTX OPK biotech oral drug delivery clinical trials FDA protein drugs
Sentiment note

Collaborative partnership with Entera Bio for oral peptide programs shows potential, but no definitive breakthrough reported

Positive Benzinga • David Phipps
NextPlat Issues Interim CEO Update Shareholder Letter

NextPlat's interim CEO David Phipps outlined strategic plans to improve healthcare and e-commerce divisions, focusing on operational efficiency, cost reduction, and exploring growth opportunities following the unexpected passing of former CEO Charles M. Fernandez.

NXPL NXPLW OPK healthcare e-commerce strategic planning operational efficiency growth opportunities
Sentiment note

Mentioned as a potential e-commerce partnership for expanding product sales into China, suggesting collaborative growth opportunities

Positive GlobeNewswire Inc. • N/A
OPKO Health to Participate in the 3rd Annual Piper Sandler Virtual Obesity Symposium

OPKO Health, Inc. and Entera Bio Ltd. announced that OPKO's ModeX Therapeutics division has formed a Scientific Advisory Board with leaders in immunology and oncology drug development. Additionally, OPKO and Entera's first-in-class dual GLP-1/Glucagon tablet candidate for obesity and metabolic disorders has been selected for presentation at the ENDO 2025 Annual Meeting.

OPK ENTX OPKO Health Entera Bio ModeX Therapeutics obesity metabolic disorders immunology
Sentiment note

The article highlights OPKO Health's participation in industry events, the formation of a Scientific Advisory Board for its ModeX Therapeutics division, and the selection of its joint product with Entera Bio for presentation at a major industry conference, indicating the company's progress and involvement in the field.

Positive GlobeNewswire Inc. • N/A
OPKO Health’s ModeX Therapeutics Announces Formation of Scientific Advisory Board with Leaders at the Forefront of Immunology and Oncology Drug Development

OPKO Health's subsidiary ModeX Therapeutics has formed a Scientific Advisory Board with renowned experts in immunology and oncology to provide guidance on the development of its multispecific antibody pipeline.

OPK OPKO Health ModeX Therapeutics Scientific Advisory Board immunology oncology multispecific antibodies
Sentiment note

OPKO Health is forming a Scientific Advisory Board for its subsidiary ModeX Therapeutics, which indicates the company is investing in the development of its immunology and oncology pipeline.

Positive GlobeNewswire Inc. • Delveinsight
Global Smart Inhalers Market to Observe Impressive Growth at a CAGR of ~21% by 2032 | DelveInsight

The smart inhalers market is experiencing significant growth, driven by the increasing incidence of respiratory diseases, technological advancements, and growing awareness of digital health solutions. North America is expected to dominate the market during the forecast period.

TEVA AZN GSK ATR smart inhalers respiratory diseases digital health North America
Sentiment note

OPKO Health, Inc. is a notable company operating in the smart inhalers market, indicating its involvement and potential contribution to the market growth.

Positive GlobeNewswire Inc. • Researchandmarkets.Com
Minimal Residual Disease Testing Market Forecast Report, 2025-2030 - Precision Medicine and Early Relapse Detection Drive MRD Testing Demand Worldwide

The Minimal Residual Disease (MRD) Testing Market is expected to grow at a CAGR of 11.18% from 2025 to 2030, driven by advancements in diagnostic technologies and the increasing focus on precision medicine and early relapse detection.

ADPT AMGN AZN TECH Minimal Residual Disease MRD Testing Precision Medicine Diagnostic Technologies
Sentiment note

The article mentions OPKO Health, Inc. as one of the leading companies driving innovation in the MRD testing market, indicating their significant contribution to the industry.

Positive GlobeNewswire Inc. • N/A
OPKO Health and Entera Bio Enter into Collaboration Agreement to Advance Oral GLP-1/Glucagon Tablet Candidate into the Clinic to Treat Obesity and Metabolic Disorders

OPKO Health and Entera Bio have entered into a collaboration agreement to advance an oral GLP-1/Glucagon dual agonist tablet into clinical trials for the treatment of obesity and metabolic disorders.

OPK ENTX OPKO Health Entera Bio GLP-1/Glucagon Obesity Metabolic Disorders
Sentiment note

OPKO Health is collaborating with Entera Bio to advance a promising oral GLP-1/Glucagon dual agonist tablet into clinical trials, which could provide a new treatment option for patients with obesity and metabolic disorders.

Positive GlobeNewswire Inc. • N/A
ModeX Therapeutics Secures $35 Million BARDA Supplement to Develop COVID Multispecific Antibodies and $16 Million to Initiate Influenza Program

ModeX Therapeutics, an OPKO Health company, has been awarded additional funding from BARDA to develop multispecific antibodies for SARS-CoV-2 and influenza. The funding will support preclinical and Phase 1 trials for these programs, which are based on ModeX's proprietary MSTAR technology.

OPK ModeX Therapeutics OPKO Health BARDA multispecific antibodies SARS-CoV-2 influenza
Sentiment note

ModeX Therapeutics is an OPKO Health company, and the additional funding for ModeX's programs is seen as a positive for OPKO Health as well, as it supports the development of innovative technologies within its portfolio.

News and sentiment labels describe article tone and are provided for research purposes only. They are not trading recommendations or forecasts.
Trade Ranks, LLC is not a registered investment adviser or broker-dealer. All rankings and AI reports are for informational and educational purposes only and are not personalized advice. Investing involves risk. Policy Portal