Several biotech companies are advancing novel cancer treatments through clinical development. Oncolytics Biotech received FDA Fast Track Designation for pelareorep in KRAS-mutant colorectal cancer, showing doubled survival benefits. Novocure gained FDA approval for Optune Pax for pancreatic cancer. Perspective Therapeutics presented positive interim data for its radiopharmaceutical VMT-α-NET. ImmunityBio launched a Phase 2 trial for its CAR-NK cell therapy combined with IL-15 superagonist. Nuvation Bio expanded its Phase 3 trial for safusidenib in IDH1-mutant glioma.

Gary Hattersley, chief scientific officer at Nuvation Bio, exercised and sold 100,000 shares under a pre-planned trading strategy, reducing his direct stock ownership to zero while retaining 298,935 stock options.

U.S. stock futures were lower this morning, with the Nasdaq futures falling by around 0.2% on Wednesday. Shares of Intel Corporation (NASDAQ: INTC) fell sharply in today’s pre-market trading after the company outlined a new financial framework for its foundry business. After the market close on Tuesday, Intel announced a new financial reporting structure designed to drive increased cost discipline and higher returns by providing greater transparency, accountability and incentives across the business. Intel shares dipped 4.8% to $41.85 in pre-market trading. Here are some big stocks recording losses in today’s pre-market trading session. Mesoblast Limited (NASDAQ:

Shares of LuxUrban Hotels Inc. (NASDAQ: LUXH) fell sharply during Wednesday’s session after the company issued preliminary fourth-quarter revenue outlook below estimates. LuxUrban said it expects preliminary revenue of $28.2 million for the fourth quarter, versus market estimates of $34.199 million, according to data from Benzinga Pro. LuxUrban Hotels shares dipped 27.4% to $1.5523 on Wednesday. Here are some other stocks moving in today's mid-day session. Gainers MariaDB plc (NYSE: MRDB) climbed 70.4% to $0.3850 after Progress Software announced that it is possibly considering an offer for the company. Lixte Biotechnology Holdings, Inc. (NASDAQ: LIXT) shares jumped 68.6% to $3.8099 after the company announced the publication of pre-clinical data on its lead clinical compound, LB-100. Nutriband Inc. (NASDAQ: NTRB) gained 33.2% to $3.9950 after the company provided a clinical and regulatory path overview for its AVERSA Fentanyl patch. Verb Technology Company, Inc. (NASDAQ: VERB) surged 30.5% to $0.3656 after the company announced that its MARKET.live entered into a formal partnership with TikTok to become a service provider for TikTok Shop and will receive a TikTok Shop Partner designation. PaySign, Inc. (NASDAQ: PAYS) gained 28.2% to $4.3299 after the company announced better-than-expected fourth-quarter results. Destiny Tech100 Inc (NASDAQ: DXYZ) rose 26.6% to $11.39 after gaining 9% on Tuesday. PAVmed Inc. (NASDAQ: PAVM) gained 19.7% to $2.4798 after the company issued business update and fourth quarter financial results. Noah Holdings Limited (NYSE: NOAH) rose 17.5% to $11.89 after the company reported fourth quarter financial results. NuScale Power Corporation (NYSE: SMR) rose 17.5% to $4.89. The ONE Group Hospitality, Inc. (NASDAQ: STKS) shares rose 17.2% to $4.70 after the company announced that it will ...

U.S. stocks were higher, with the Dow Jones index gaining around 300 points on Wednesday. Shares of Cintas Corporation (NASDAQ: CTAS) rose sharply during Wednesday’s session after the company reported better-than-expected third-quarter financial results and raised FY24 guidance. Cintas posted GAAP earnings of $3.84 per share, beating market estimates of $3.59 per share. The company’s quarterly sales came in at $2.406 billion, versus expectations of $2.386 billion, according to data from Benzinga Pro. Cintas shares climbed 9.7% to $694.62 on Wednesday. Here are some other big stocks recording gains in today’s session. PaySign, Inc. (NASDAQ: PAYS) shares jumped 28.2% to $4.3299 after the company announced better-than-expected fourth-quarter results. Noah Holdings Limited (NYSE: NOAH) climbed 17.5% to $11.89 ...

Top Wall Street analysts changed their outlook on these top names. For a complete view of all analyst rating changes, including upgrades and downgrades, please see our analyst ratings page. Barclays cut the price target for Prologis, Inc. (NYSE: PLD) from $153 to $141. Barclays analyst Anthony Powell maintained an Overweight rating. Prologis shares fell 1.6% to close at $125.14 on Tuesday. See how other analysts view this stock. Truist Securities slashed the price target for Berry Global Group, Inc. (NYSE: BERY) from $75 to $68. Truist Securities analyst Michael Roxland downgraded the stock from Buy to Hold. Berry Global shares fell 0.4% to close at $59.23 on Tuesday. See how other analysts view this stock. Wedbush increased Netflix, Inc. (NASDAQ: NFLX) price target from $615 to $725. Wedbush analyst Michael Pachter maintained an Outperform rating. Netflix shares rose 0.3% to close at $629.24 on Tuesday. See how other analysts view this stock. Keefe, Bruyette & Woods boosted the price target ...

Shares of MariaDB plc (NYSE: MRDB) rose sharply in today’s pre-market trading after Progress Software (NASDAQ: PRGS) announced that it is possibly considering an offer for the company. MariaDB shares jumped 100.4% to $0.4530 in pre-market trading Here are some other stocks moving in pre-market trading. Gainers Destiny Tech100 Inc (NASDAQ: DXYZ) rose 52.9% to $13.76 in pre-market trading after gaining 9% on Tuesday. PaySign, Inc. (NASDAQ: PAYS) gained 25.2% to $4.23 in pre-market trading after the company announced better-than-expected fourth-quarter results. Hitek Global Inc. (NASDAQ: HKIT) gained 19.1% to $1.69 in pre-market trading. The ONE Group Hospitality, Inc. (NASDAQ: STKS) shares rose 13.2% to $4.54 in pre-market trading after the company announced that it will acquire Safflower Holdings. nCino, Inc. (NASDAQ: NCNO) gained 11.7% to $33.72 in pre-market trading as the company reported better-than-expected fourth-quarter results and issued FY25 adjusted earnings guidance above estimates.. Nuvation Bio Inc. (NASDAQ: NUVB) shares rose 11.5% to $3.21 in pre-market trading. Nuvation Bio shares gained 28% on Tuesday after BTIG upgraded the stock from Neutral ...

Shares of Westport Fuel Systems Inc. (NASDAQ: WPRT) fell sharply during Tuesday’s session after posting a wider-than-expected fourth-quarter loss. Westport Fuel Systems posted a quarter loss of 81 cents per share, compared to market expectations for a loss of 51 cents per share. Westport Fuel Systems shares dipped 9.9% to $6.52 on Monday. Here are some other stocks moving in today's mid-day session. Gainers Stoke Therapeutics, Inc. (NASDAQ: STOK) shares gained 72.6% to $11.24 after the company announced Phase 1/2a data supporting the potential for STK-001 in Dravet syndrome. C3is Inc. (NASDAQ: CISS) climbed 65% to $0.0581 after the company reported a year-over-year increase in fourth-quarter financial results. OpGen, Inc. (NASDAQ: OPGN) shares climbed 48.2% to $0.7039 after the company entered into a securities purchase agreement with a private investor, David Lazar, to acquire 3 million shares of Series E Convertible Preferred Stock at $1.00 per share for aggregate gross proceeds of $3.0 million. Mesoblast Limited (NASDAQ: MESO) gained 43.2% to $3.1501. Mesoblast was notified by the U.S. FDA that available clinical data from Phase 3 trial appear sufficient to support BLA submission for Remestemcel-L in children with steroid-refractory acute graft versus host disease. Praxis Precision Medicines Inc (NASDAQ: PRAX) gained 31.9% to $66.63 after the company reported results from a Phase 2a proof of concept study evaluating PRAX-628 in epilepsy patients with PPR. Nuvation Bio Inc (NYSE: NUVB) climbed 24.4% to $2.80 after BTIG upgraded the stock from Neutral to Buy. Check-Cap Ltd. (NASDAQ: CHEK) shares gained 24.3% to $2.40 after the company announced that it entered into a definitive Business Combination Agreement with Nobul AI. Viking Therapeutics ...

U.S. stocks were higher, with the Dow Jones index gaining around 50 points on Tuesday. Shares of Tesla Inc (NASDAQ: TSLA) rose sharply during Tuesday’s session amid reports suggest Italy has approached the company about electric truck production. Multiple reports are highlighting new reporting from Italian news outlet Il Sole 24 Ore, suggesting Italy’s Industry Ministry officials have reached out to Tesla in regards to potentially manufacturing electric trucks in the country. Tesla shares surged 5.8% to $182.65 on Tuesday. Here are some other big stocks recording losses in today’s session. Praxis Precision Medicines Inc (NASDAQ: PRAX) shares jumped 31.9% to $66.63 after the company reported results from a Phase 2a proof of concept study evaluating PRAX-628 in epilepsy patients with PPR. Nuvation Bio Inc (NYSE: NUVB) surged 24.4% to $2.80 after BTIG upgraded the stock from Neutral to Buy. Krispy Kreme, Inc. ...

U.S. stock futures were lower this morning, with the Dow futures falling by around 50 points on Monday. Shares of Esperion Therapeutics, Inc. (NASDAQ: ESPR) rose sharply in today’s pre-market trading. The U.S. FDA approved broad new labels for Esperion's NEXLETOL® and NEXLIZET® to prevent heart attacks and cardiovascular procedures in both primary and secondary prevention patients, regardless of statin use. Esperion Therapeutics shares jumped 12.7% to $2.58 in pre-market trading. Here are some big stocks recording gains in today’s pre-market trading session. Forge Global Holdings, Inc. (NYSE: FRGE) shares gained 22.8% to $2.86 in pre-market trading ...

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The Dow Jones closed lower by more than 300 points on Thursday. When insiders purchase or sell shares, it indicates their confidence or concern around the company's prospects. Investors and traders interested in penny stocks can consider this a factor in their overall investment or trading decision. Below is a look at a few recent notable insider transactions for penny stocks. For more, check out Benzinga's insider transactions platform. Eos Energy Enterprises The Trade: Eos Energy Enterprises, Inc. (NASDAQ: EOSE) CEO Joe Mastrangelo acquired a total of 36,500 shares an average price of $2.05. To acquire these shares, it cost around $74,810. What’s Happening: Eos was selected by Dominion Energy Virginia to provide 16 MWh of storage in a pilot project to strengthen the ...