JAZZ
Jazz Pharmaceuticals plc · Healthcare · Biotechnology
At close
$226.08
−$0.05 (−0.02%) Close
Pre-market $226.12 +$0.05 (+0.02%) 8:10 PM ET
Prev close $226.12
Open $226.08
Day high $226.08
Day low $226.08
Volume 17
Avg vol 946,631
Mkt cap
$14.19B
P/E ratio
2,055.23
FY Revenue
$4.44B
EPS
0.11
Gross Margin
88.00%
Sector
Healthcare
AI report sections
JAZZ
Jazz Pharmaceuticals plc
Jazz Pharmaceuticals shows very strong recent price performance with the stock trading near its 52-week high and well above key moving averages, while momentum indicators indicate an overbought backdrop that may increase near-term volatility. Fundamentally, the company combines high gross margins and solid free cash flow generation with weak accounting profitability and a very elevated P/E multiple. Short interest metrics point to meaningful bearish positioning and a high short volume ratio, which can amplify both upside and downside moves.
AI summarized at 3:56 PM ET, 2026-05-19
AI summary scores
INTRADAY: 72 SWING: 78 LONG: 63
Volume vs average
Intraday (cumulative)
+81% (Above avg)
Vol/Avg: 1.81×
RSI
61.59 (Strong)
Strong (60–70)
MACD momentum
Intraday
-0.11 (Weak)
MACD: -0.11 Signal: 0.00
Short-Term
-1.06 (Weak)
MACD: 8.31 Signal: 9.37
Long-Term
+0.08 (Strong)
MACD: 14.74 Signal: 14.66
Intraday trend score 48.20

Latest news

JAZZ 12 articles Positive: 5 Neutral: 7 Negative: 0
Neutral GlobeNewswire Inc. • Na
Zymeworks Announces Participation in Upcoming Investor Conferences

Zymeworks Inc. announced its participation in three upcoming investor conferences: the 2026 Stifel Virtual Targeted Oncology Forum (May 20), TD Cowen 7th Annual Oncology Innovation Summit (May 27), and 2026 Jefferies Global Healthcare Conference (June 3). The company will engage in fireside chats and one-on-one meetings to discuss its portfolio of licensed healthcare assets and pipeline of novel biotherapeutics.

ZYME JAZZ ONC investor conference biotherapeutics oncology zanidatamab HER2-targeted
Sentiment note

Jazz Pharmaceuticals is mentioned only as a partner with exclusive commercialization rights for zanidatamab in certain territories. No specific updates or developments regarding Jazz are provided in the main article content.

Positive GlobeNewswire Inc. • Delveinsight
Pheochromocytoma and Paraganglioma Market to Exhibit Growth at 7.3% CAGR by 2036 Driven by the Advent of Drug Classes Such as SSTR2 analogs, Dopamine Receptor D2 Agonists, TAAs or TSAs, and Others | DelveInsight

The pheochromocytoma and paraganglioma (PCPG) market is projected to grow at 7.3% CAGR through 2036, driven by emerging therapies including radioligand treatments, HIF-2α inhibitors, and targeted agents. The market was valued at USD 300 million in 2025 across seven major markets, with the US accounting for 67% of the market. Key companies including Novartis, Jazz Pharmaceuticals, Perspective Therapeutics, and Merck are advancing innovative treatments, with WELIREG (belzutifan) expected to generate the highest revenue by 2036.

JAZZ CATX MRK BHC pheochromocytoma paraganglioma PCPG market radioligand therapy
Sentiment note

Jazz Pharmaceuticals is advancing JZP3507 (ONC206), an investigational dual-mechanism oncology agent being assessed in early-phase clinical trials for PCPG and other hard-to-treat malignancies, positioning the company to capture market share in this growing therapeutic area.

Neutral GlobeNewswire Inc. • Not Specified
Artios Strengthens Leadership Team to Accelerate Late-Stage Development of Potential First-in-Class Oncology Pipeline

Artios Pharma appointed three senior leaders to strengthen late-stage development capabilities: Roy W. Ware as Chief Manufacturing and Technology Officer, Caryn Barnett as VP of Clinical Operations, and Pablo Lee as VP of Medical Affairs. These appointments aim to accelerate the company's DDR-based oncology pipeline, particularly alnodesertib, toward potential commercialization and FDA approval.

JAZZ LLY DNA Damage Response (DDR) oncology pipeline alnodesertib ART6043 clinical development FDA approval
Sentiment note

Mentioned only as the acquirer of Chimerix (where the new CMTO previously worked). No direct business impact or news related to Jazz Pharmaceuticals is discussed in the article.

Neutral GlobeNewswire Inc. • Na
Zymeworks To Report Fourth Quarter and Full Year 2025 Financial Results and Host Conference Call on March 2, 2026

Zymeworks Inc. announced it will report its fourth quarter and full year 2025 financial results on March 2, 2026, followed by a conference call at 8:30 am ET. The biotechnology company is managing a portfolio of licensed healthcare assets and developing multifunctional biotherapeutics, with key products including Ziihera and partnerships with BeOne Medicines and Jazz Pharmaceuticals for commercialization rights.

ZYME ONC JAZZ financial results fourth quarter 2025 biotherapeutics Ziihera zanidatamab
Sentiment note

Jazz Pharmaceuticals is mentioned only as a partner with exclusive commercialization rights for zanidatamab in certain territories. No specific information about their performance or involvement is provided.

Positive The Motley Fool • Dan Caplinger
Harmony Biosciences' Sales and Profits Have Soared. Why Hasn't Its Stock Followed?

Harmony Biosciences has achieved remarkable financial success with its narcolepsy drug Wakix, growing sales at 40% CAGR to nearly $870 million and achieving profitability with $186 million in net income. However, the stock has remained flat since its IPO due to concerns including a 2023 short-seller report alleging fraud, pending patent expiration in 2030, and intense competition from Jazz Pharmaceuticals' blockbuster treatments Xywav and Xyrem.

HRMY JAZZ biotech narcolepsy treatment Wakix patent expiration short-seller report pharmaceutical competition
Sentiment note

Jazz maintains market leadership in narcolepsy treatment with blockbuster drugs Xywav and Xyrem generating $1.3 billion in revenue in the first nine months of 2025. The company has greater market share than Harmony and physician preference, positioning it favorably against competition.

Neutral GlobeNewswire Inc. • Na
Zymeworks Announces Participation in Upcoming Investor Conferences

Zymeworks Inc. announced that its management will participate in multiple investor conferences in February and March 2026, including Citi's Virtual Oncology Leadership Summit, TD Cowen Health Care Conference, Leerink Global Healthcare Conference, and Citizens Life Science Conference. The company continues to advance its portfolio of licensed healthcare assets and biotherapeutics pipeline.

ZYME ONC JAZZ investor conferences biotherapeutics Ziihera zanidatamab HER2-targeted
Sentiment note

Mentioned as a partner with exclusive rights to develop and commercialize zanidatamab in different territories. The mention is factual without conveying positive or negative sentiment.

Positive Benzinga • Vandana Singh
Jazz Pharmaceuticals' Drug Extends Survival Past Two Years in Advanced Stomach Cancer Trial

Jazz Pharmaceuticals announced positive Phase 3 trial results for Ziihera (zanidatamab-hrii) in treating HER2-positive gastroesophageal adenocarcinoma. The triplet therapy combining Ziihera with tislelizumab and chemotherapy achieved a median overall survival of 26.4 months, the longest reported in a Phase 3 GEA trial, representing a 28% reduction in death risk. The doublet therapy also showed strong results with median OS of 24.4 months. Jazz shares rose 2.07% following the announcement.

JAZZ ZYME Phase 3 trial gastroesophageal adenocarcinoma Ziihera overall survival HER2-positive cancer clinical trial results
Sentiment note

Announced positive Phase 3 trial results showing unprecedented median overall survival of 26.4 months for triplet therapy, representing significant improvement over control arm. Stock price increased 2.07% on the news.

Positive GlobeNewswire Inc. • Zymeworks Inc.
Ziihera® (zanidatamab-hrii) Combinations Achieve Unprecedented Results in First-Line HER2+ Locally Advanced or Metastatic GEA including more than Two Years Median Overall Survival Benefit

Zymeworks announced positive Phase 3 HERIZON-GEA-01 results for Ziihera (zanidatamab-hrii) in combination with chemotherapy, with or without tislelizumab, for first-line treatment of HER2-positive gastroesophageal adenocarcinoma. The trial demonstrated statistically significant improvements in progression-free survival (approximately 35% risk reduction) and overall survival (26.4 months median, representing a 7+ month improvement over trastuzumab). Zymeworks is eligible to receive up to $440 million in milestone payments from regulatory approvals across major markets.

ZYME JAZZ ONC HER2-positive gastroesophageal cancer zanidatamab Phase 3 trial overall survival benefit first-line treatment
Sentiment note

As co-developer and commercialization partner for Ziihera in certain territories, Jazz benefits from positive Phase 3 data supporting regulatory submissions and potential market approval for a first-line HER2+ GEA treatment with significant clinical advantages over current standard of care.

Neutral GlobeNewswire Inc. • Zymeworks Inc.
Zymeworks Announces Participation in Upcoming Investor Conferences

Zymeworks Inc. will participate in two upcoming healthcare investor conferences in Miami, including one-on-one meetings and fireside chats, highlighting their biotechnology portfolio and licensed healthcare assets.

ZYME ONC JAZZ biotechnology healthcare investor conferences biotherapeutics licensed assets
Sentiment note

Mentioned as a partner with exclusive rights to develop and commercialize zanidatamab in different territories

Positive Benzinga • Vandana Singh
Zymeworks, Jazz Pharmaceuticals Stocks Climb On Robust Gastroesophageal Trial Outcomes And Upcoming Regulatory Plans

Zymeworks, Jazz Pharmaceuticals, and BeOne Medicines reported positive Phase 3 trial results for Ziihera in treating HER2-positive gastroesophageal adenocarcinoma, demonstrating significant improvements in progression-free and overall survival.

ZYME JAZZ ONC gastroesophageal cancer clinical trial HER2-positive pharmaceutical
Sentiment note

Stock increased 20.45% following promising trial outcomes and plans to submit data for regulatory approval

Neutral GlobeNewswire Inc. • Zymeworks Inc.
Zymeworks Announces Participation in Upcoming Investor Conferences

Zymeworks, a clinical-stage biotechnology company, announced participation in upcoming investor conferences and highlighted its progress in developing biotherapeutics for cancer and other diseases, including the FDA-approved zanidatamab for biliary tract cancer.

ZYME ONC JAZZ biotechnology biotherapeutics cancer zanidatamab clinical trials
Sentiment note

Mentioned as having an exclusive partnership with Zymeworks for zanidatamab development

Neutral Benzinga • Vandana Singh
Alkermes Strikes $2.1 Billion Avadel Deal, Gains Access To Narcolepsy Drug Lumryz

Alkermes agreed to acquire Avadel Pharmaceuticals for up to $20 per share, valuing the deal at $2.1 billion. The acquisition includes the narcolepsy drug Lumryz and is expected to close in Q1 2026, with potential additional payment contingent on FDA approval.

ALKS AVDL JAZZ acquisition narcolepsy pharmaceutical drug development FDA approval
Sentiment note

Settling litigation and receiving $90 million, but losing potential future royalties

News and sentiment labels describe article tone and are provided for research purposes only. They are not trading recommendations or forecasts.
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