The head and neck squamous cell carcinoma (HNSCC) market is expected to grow at a CAGR of 10.5% from 2026-2036, driven by rising cancer incidence, increased adoption of immunotherapies, and the launch of emerging novel treatments. The market was valued at USD 850 million in 2025 across seven major markets, with KEYTRUDA currently generating the highest revenue. Multiple companies are advancing innovative therapies targeting HPV16-positive HNSCC and other molecular pathways.

The European Commission has approved TEPKINLY® (epcoritamab) in combination with lenalidomide and rituximab for treating relapsed or refractory follicular lymphoma. The Phase 3 EPCORE® FL-1 trial demonstrated that the fixed-duration combination therapy reduced disease progression or death risk by 79% compared to standard care, with 96% overall response rate and 74% complete response rate, offering a chemotherapy-free treatment option.

Genmab announced positive Phase 2 and Phase 1b/2 trial results for epcoritamab in elderly DLBCL patients. The monotherapy arm (EPCORE DLBCL-3) showed 67% overall response rate and 58% complete response rate, while the combination with R-mini-CHOP (EPCORE NHL-2) demonstrated 93% overall response rate and 86% complete response rate with durable remissions and sustained MRD negativity.

Genmab A/S announced the disclosure of share transactions made by managerial employees and their closely associated persons in accordance with EU market abuse regulations. The company also announced a capital increase of 2,346 shares resulting from employee warrant exercises.

The bispecific antibody drug conjugate (BsADC) market is expected to reach over $2 billion by 2030, with the first BsADC approval anticipated by 2028. Over 150 clinical trials are underway globally, with China leading development efforts. Key candidates like Izalontamab brengitecan and JSKN003 are showing positive clinical results in cancer treatment, positioning BsADCs as the next generation of targeted therapies.

The bispecific antibodies market is projected to reach over $60 billion by 2031, growing from $16 billion in 2025. With 18 approved bispecific antibodies and over 550 clinical trials underway, the market is transitioning toward commercial maturity driven by clinical progress in cancer, autoimmune, and inflammatory therapies. Major pharmaceutical players and emerging biotech companies are actively expanding their pipelines through strategic collaborations and technological innovation.

Genmab A/S has completed a share capital reduction by canceling 1.9 million treasury shares, reducing total share capital from DKK 64.25 million to DKK 62.35 million. The reduction was approved at the Annual General Meeting on March 19, 2026, and registered with Danish authorities on April 17, 2026. Nasdaq systems will be updated by April 21, 2026.

Orbis Investment Management Limited has disclosed a 4.99% stake in Genmab A/S as of March 27, 2026, controlling 3,205,763 shares. The announcement was made under Danish Capital Markets Act requirements. Genmab also held its Annual General Meeting on March 19, 2026, where the 2025 Annual Report was approved and discharge was given to the Board of Directors and Executive Management.

Genmab A/S issued a correction to a previous company announcement regarding managerial employee share transactions, correcting the reported share price from DKK 0.00 to DKK 1,867.50. The announcement discloses vesting and net settlement of restricted stock units granted to executives Jan van de Winkel and Anthony Pagano in February 2023.

Genmab A/S announced the vesting and net settlement of restricted stock units (RSUs) granted to executives Jan van de Winkel and Anthony Pagano on February 24, 2023, as part of deferred annual bonus achievement. The disclosure is made in accordance with EU market abuse regulations requiring transparency of insider trading activities.

The global targeted cancer therapy market is projected to grow from USD 90.89 billion in 2025 to USD 175.48 billion by 2035 at a CAGR of 6.80%. Growth is driven by antibody-drug conjugates (ADCs), KRAS inhibitors, bispecific antibodies, and regulatory productivity. Monoclonal antibodies capture 43% revenue share, lung cancer represents 32% of the market, and hospitals account for 58% of end-user share. North America dominates with 39% market share.

Genmab announced topline results from the Phase 3 EPCORE DLBCL-1 trial showing epcoritamab demonstrated improvement in progression-free survival (HR: 0.74) in relapsed/refractory DLBCL patients. However, overall survival did not reach statistical significance (HR: 0.96). The company will engage regulatory authorities to discuss next steps, with additional Phase 3 trial data expected in 2026.