The acute ischemic stroke market is expected to grow significantly through 2036, driven by increased symptom awareness, advances in acute stroke care, and a robust pipeline of innovative therapies. Key candidates in development include lenzocimab, DM199, milvexian, and BB-031. The US accounts for the largest market share, with approximately 1.8 million incident cases across the 7MM in 2025. Recent developments include FDA approval of tenecteplase in March 2025 and encouraging Phase 2 results for LT3001.

DiaMedica (DMAC) rises 10% as it doses the first patient in the relaunch of its pivotal study evaluating the lead candidate, DM199, to treat acute ischemic stroke.

DiaMedica Therapeutics (DMAC) is technically in oversold territory now, so the heavy selling pressure might have exhausted. This along with strong agreement among Wall Street analysts in raising earnings estimates could lead to a trend reversal for the stock.

Here is how Cardiol Therapeutics Inc. (CRDL) and DiaMedica Therapeutics, Inc. (DMAC) have performed compared to their sector so far this year.

Here is how DiaMedica Therapeutics, Inc. (DMAC) and DermTech, Inc. (DMTK) have performed compared to their sector so far this year.

Upgrades For DiaMedica Therapeutics Inc (NASDAQ:DMAC), Oppenheimer upgraded the previous rating of Perform to Outperform. In the first quarter, DiaMedica Therapeutics showed an EPS of $0.20, compared to $0.13 from the year-ago quarter. At the moment, the stock has a 52-week-high of $4.05 and a 52-week-low of $1.12. DiaMedica Therapeutics closed at $3.64 at the end of the last trading period. For Kellogg Co (NYSE:K), Bernstein upgraded the previous rating of Underperform to Market Perform. For the first quarter, Kellogg had an EPS of $1.10, compared to year-ago quarter EPS of $1.10. At the moment, the stock has a 52-week-high of $77.16 and a 52-week-low of $63.74. Kellogg closed at $65.24 at the end of the last trading period. For Agree Realty Corp (NYSE:ADC), Mizuho upgraded the previous rating of Neutral to Buy. Agree Realty earned $0.98 in the first quarter, compared to $0.97 in the year-ago quarter. At the moment, the stock has a 52-week-high of $80.41 and a 52-week-low of $63.34. Agree Realty closed at $65.19 at the end of the last trading period. For Grab Holdings Inc (NASDAQ:GRAB), JP Morgan upgraded the previous rating of Underweight to Neutral. In the first quarter, Grab Hldgs showed an EPS of $0.06, compared to $0.11 from the year-ago quarter. At the moment, the stock has a 52-week-high of $4.03 and a 52-week-low of $2.19. Grab Hldgs closed at $3.39 at the end of the last trading period. For XP Inc (NASDAQ:XP), B of A Securities upgraded the previous rating of Neutral to Buy. For the first quarter, XP had an EPS of $0.28, compared to year-ago quarter EPS of $0.28. The current stock performance of XP shows a 52-week-high of $25.18 and a 52-week-low of $10.30. Moreover, at the end of the last trading period, the closing price was at $24.52. See all analyst ratings upgrades. Downgrades For Dow Inc (NYSE:DOW), B of A Securities downgraded the previous rating of Neutral to Underperform. For the first quarter, Dow had an EPS of $0.58, compared to year-ago quarter EPS of $2.34. At the moment, the stock has a 52-week-high of $60.88 and a 52-week-low of $42.92. Dow closed at $51.88 at the end of the last trading period. For The AES Corp (NYSE:AES), B of A Securities downgraded the previous rating of Buy to Neutral. In the first quarter, AES showed an EPS of $0.22, compared to $0.21 from the year-ago quarter. The current stock performance of AES shows a 52-week-high of $29.87 and a 52-week-low of $18.91. Moreover, at the end of the last trading period, the closing price was at $20.98. For Celanese Corp (NYSE:CE), B of A Securities downgraded the previous rating of Buy to Neutral. Celanese earned $2.01 in the first quarter, compared to $5.54 in the year-ago quarter. The stock has a 52-week-high of $128.35 and a 52-week-low of $86.73. At the end of the last trading period, Celanese closed at $108.52. For The Chemours Co (NYSE:CC), B of A Securities downgraded the previous rating of Buy to Neutral. Chemours earned $0.98 in the first quarter, compared to $1.46 in the year-ago quarter. The stock has a 52-week-high of $38.34 and a 52-week-low of $23.60. At the end of the last trading period, Chemours closed at $33.95. For Enphase Energy Inc (NASDAQ:ENPH), OTR Global downgraded the previous rating of Mixed to Negative. For the first quarter, Enphase Energy had an EPS of $1.37, compared to year-ago quarter EPS of $0.79. At the moment, the stock has a 52-week-high of $339.88 and a 52-week-low of $152.15. Enphase Energy closed at $167.99 at the end of the last trading period. According to BMO Capital, the prior rating for Xcel Energy Inc (NASDAQ:XEL) was changed from Outperform to Market Perform. Xcel Energy earned $0.76 in the first quarter, compared to $0.70 in the year-ago quarter. At the moment, the stock has a 52-week-high of $77.63 and a 52-week-low of $56.92. Xcel Energy closed at $62.81 at the end of the last trading period. According to Oppenheimer, the prior rating for Equinix Inc (NASDAQ:EQIX) was changed from Outperform to Perform. For the first quarter, Equinix had an EPS of $8.59, compared to year-ago quarter EPS of $7.16. The current stock performance of Equinix shows a 52-week-high of $792.02 and a 52-week-low of $495.11. Moreover, at the end of the last trading period, the closing price was at $768.00. According to Morgan Stanley, the prior rating for Tesla Inc (NASDAQ:TSLA) was changed from Overweight to Equal-Weight. In the first quarter, Tesla showed ...Full story available on Benzinga.com

The Dow Jones closed lower by around 200 points on Thursday. Investors, meanwhile, focused on some notable insider trades. When insiders purchase or sell shares, it indicates their confidence or concern around the company's prospects. Investors and traders interested in penny stocks can consider this a factor in their overall investment or trading decision. Below is a look at a few recent notable insider transactions for penny stocks. For more, check out Benzinga's insider transactions platform. DiaMedica Therapeutics The Trade: DiaMedica Therapeutics Inc. (NASDAQ: DMAC) Director Michael Randall Giuffre bought a total of 67,228 ...

DiaMedica Therapeutics, Inc. (DMAC) might move higher on growing optimism about its earnings prospects, which is reflected by its upgrade to a Zacks Rank #2 (Buy).

Gainers UserTesting, Inc. (NYSE: USER) shares jumped 91.7% to close at $7.40 after the company announced it will be acquired by Thoma Bravo and Sunstone Partners for $1.3 billion. The company also reported better-than-expected Q3 sales results. AgroFresh Solutions, Inc. (NASDAQ: AGFS) climbed 71.3% to close at $2.69 after the company announced its board of directors agreed with Paine Schwartz Partners to pursue acquisition of the company for $3 per share. HeartCore Enterprises, Inc. (NASDAQ: HTCR) shares jumped 57.3% to close at $1.51 on Thursday after the company announced it entered into a license agreement with Transcosmos Digital Technology for its Apromore process mining tool. Altra Industrial Motion Corp. (NASDAQ: AIMC) surged 48.4% to close at $59.72 after the company announced it will be acquired by Regal Rexnord Corporation for $62 per share in cash. Rail Vision Ltd. (NASDAQ: RVSN) gained 36.5% to settle at $0.6827. mCloud Technologies Corp. (NASDAQ: MCLD) gained 31.6% to close at $1.24 after the company announced a partnership with Google to launch three AI-powered sustainability applications combining the company's AssetCare platform with Google Cloud and additional Google services. Impinj, Inc. (NASDAQ: PI) jumped 29.2% to settle at $115.30 after the company reported better-than-expected Q3 EPS and sales results. The company also issued Q4 sales guidance above analyst estimates. View, Inc. (NASDAQ: VIEW) jumped 28.9% to close at $1.36. Community Health Systems, Inc. (NYSE: CYH) jumped 26.1% to close at $2.90 following Q3 results. Eqonex Limited (NASDAQ: EQOS) gained 24.7% to close at $0.5860. Acorda Therapeutics, Inc. (NASDAQ: ACOR) rose 21.7% to close at $0.59. Acorda Therapeutics said it sees FY22 sales of $116 million to $119.7 million. LMF Acquisition Opportunities, Inc. (NASDAQ: LMAO) jumped 21% to close at $10.89. BigBear.ai Holdings, Inc. (NYSE: BBAI) gained 20.7% to close at $1.40. Cyclerion Therapeutics, Inc. (NASDAQ: CYCN) rose 19.6% to close at $0.5380. The Greenbrier Companies, Inc. (NYSE: GBX) climbed 19.1% to close at $32.87 after the company reported better-than-expected Q4 EPS and sales results. NeuroBo Pharmaceuticals, Inc. (NASDAQ: NRBO) rose 18.2% to close at $9.76. Shopify Inc. (NYSE: SHOP) gained 17.3% to close at $34.10 after the company reported better-than-expected Q3 EPS results and issued guidance. Frontier Group Holdings, Inc. (NASDAQ: ULCC) gained 16.5% to close at $11.87 after the company reported better-than-expected Q3 EPS results. Oceaneering International, Inc. (NYSE: OII) shares climbed 16.5% to close at $13.08 after the company reported better-than-expected Q3 EPS and sales results. NuZee, Inc. (NASDAQ: NUZE) gained 15.2% to close at $0.3802. Aeglea BioTherapeutics, Inc. (NASDAQ: AGLE) rose 15.1% to settle at $0.57. Arch Resources, Inc. (NYSE: ARCH) gained 14.2% to close at $151.93 after the company reported better-than-expected Q3 sales. Goosehead Insurance, Inc (NASDAQ: GSHD) climbed 13.8% to close ...

Gainers Green Giant Inc. (NASDAQ: GGE) jumped 161.1% to close at $1.88 after dipping 29% on Wednesday. Atlis Motor Vehicles, Inc. (NASDAQ: AMV) climbed 95.5% to close at $24.49. InVivo Therapeutics Holdings Corp. (NASDAQ: NVIV) gained 83% to settle at $7.98. Pineapple Energy Inc. (NASDAQ: PEGY) shares climbed 64.9% to close at $4.55 after jumping 93% on Wednesday. Pineapple Energy recently named Eric Ingvaldson as new Chief Financial Officer. WM Technology, Inc. (NASDAQ: MAPS) rose 64.3% to close at $2.76. Statera Biopharma, Inc. (NASDAQ: STAB) gained 62.8% to close at $0.2283 on Thursday. Statera Biopharma was recently granted European patent number EP3206708 titled "Methods And Compositions For The Treatment Of Radiation-Related Disorders." Code Chain New Continent Limited (NASDAQ: CCNC) shares gained 46.6% to close at $0.2465. SpringBig Holdings, Inc. (NASDAQ: SBIG) jumped 44.2% to close at $1.19. Kiromic BioPharma, Inc. (NASDAQ: KRBP) gained 44.3% to close at $0.3923 after the company announced it received feedback from the FDA pursuant to its Type B Pre-IND meeting request regarding its Deltacel development strategy. Clever Leaves Holdings Inc. (NASDAQ: CLVR) jumped 36.7% to settle at $0.8198. Motus GI Holdings, Inc. (NASDAQ: MOTS) rose 38.3% to close at $2.60 after the company was granted a Us patent titled 'Cleaning Method for Prepless Colonoscopy.' Guardion Health Sciences, Inc. (NASDAQ: GHSI) jumped 31% to close at $0.1808 as the company announced clinical results indicating viactiv omega boost gel bites showed increase in Omega-3 levels in 4 weeks. Tilray Brands, Inc. (NASDAQ: TLRY) gained 30.9% to settle at $3.90. Shares of cannabis companies traded higher after President Biden issued a statement on marijuana reform, which mentioned pardoning 'all prior federal offenses of simple marijuana possession.' SAI.TECH Global Corporation (NASDAQ: SAI) rose 30.4% to settle at $4.89. BioSig Technologies, Inc. (NASDAQ: BSGM) jumped 28.8% to settle at $0.88. Addentax Group Corp. (NASDAQ: ATXG) gained 28.4% to close at $3.44. COMSovereign Holding Corp. (NASDAQ: COMS) rose 26.9% to settle at $0.0773. HeartBeam, Inc. (NASDAQ: BEAT) shares climbed 26.5% to close at $5.73 after the company announced it expanded its product portfolio pipeline to include smartwatch connectivity. DAVIDsTEA Inc. (NASDAQ: DTEA) climbed 26% to close at $0.8948. WeTrade Group, Inc. (NASDAQ: WETG) rose 25.8% to close at $1.16. Provention Bio, Inc. (NASDAQ: PRVB) surged 25.7% to close at $6.22 after the company announced it has entered into a co-promotion agreement with Sanofi U.S. for the launch of its lead investigational drug candidate teplizumab. The Valens ...

Gainers Statera Biopharma, Inc. (NASDAQ: STAB) rose 98% to $0.2777. Statera Biopharma was recently granted European patent number EP3206708 titled "Methods And Compositions For The Treatment Of Radiation-Related Disorders." Code Chain New Continent Limited (NASDAQ: CCNC) shares rose 93% to $0.3245. Motus GI Holdings, Inc. (NASDAQ: MOTS) gained 46% to $2.7500 after the company was granted a US patent titled 'Cleaning Method for Prepless Colonoscopy.' Atlis Motor Vehicles, Inc. (NASDAQ: AMV) gained 41.2% to $17.69. Revelation Biosciences, Inc. (NASDAQ: REVB) gained 29.1% to $0.3273 after the company announced an exclusive worldwide license agreement with Vanderbilt University to develop and commercialize phosphorylated hexaacyl disaccharide, for treating or preventing infections. Pineapple Energy Inc. (NASDAQ: PEGY) shares climbed 27.9% to $3.53 after jumping 93% on Wednesday. Pineapple Energy recently named Eric Ingvaldson as new Chief Financial Officer. Green Giant Inc. (NASDAQ: GGE) rose 27.5% to $0.9179 after dipping 29% on Wednesday. Kiromic BioPharma, Inc. (NASDAQ: KRBP) rose 25.1% to $0.34 after the company announced it received feedback from the FDA pursuant to its Type B Pre-IND meeting request regarding its Deltacel development strategy. Lixiang Education Holding Co., Ltd. (NASDAQ: LXEH) jumped 23.3% to $3.3999. Lixiang Education Holding recently posted 1H loss of $0.01 per share. HeartBeam, Inc. (NASDAQ: BEAT) shares gained 23.3% to $5.58 after the company announced it expanded its product portfolio pipeline to include smartwatch connectivity. Provention Bio, Inc. (NASDAQ: PRVB) surged 21.3% to $6.01 after the company announced it has entered into a co-promotion agreement with Sanofi U.S. for the launch of its lead investigational drug candidate teplizumab. WISeKey International Holding ...

U.S. stock futures traded lower this morning on Friday. Investors, meanwhile, focused on some notable insider trades. When insiders purchase or sell shares, it indicates their confidence or concern around the company's prospects. Investors and traders interested in penny stocks can consider this a factor in their overall investment or trading decision. Below is a look at a few recent notable insider transactions for penny stocks. For more, check out Benzinga's insider transactions platform.3 Troika Media The Trade: Troika Media Group, Inc. (NASDAQ: TRKA) 10% owner Peter Coates acquired a total of 500,000 shares at an ...