AZN
AstraZeneca PLC · Healthcare · Drug Manufacturers - General
Last
$162.15
−$2.37 (−1.44%) 4:00 PM ET
Prev close $164.52
Open $163.61
Day high $163.61
Day low $161.21
Volume 2,854,111
Avg vol 3,786,048
Mkt cap
$252.33B
EV/Sales
11.11
P/E ratio
113.61
FY Revenue
$24.06B
EPS
1.43
Gross Margin
80.38%
Div yield
1.40%
Sector
Healthcare
AI report sections
AZN
AstraZeneca PLC
AstraZeneca PLC combines a large global footprint and diversified therapeutic portfolio with near-term price consolidation and pressured recent fundamentals. The share price sits well above its 50-day moving average after a very strong 3–6 month advance, yet momentum indicators and intraday pattern signals point to a cooling phase below VWAP. Valuation multiples are elevated across earnings, sales, and cash flow, while balance sheet leverage and liquidity metrics indicate moderate financial risk despite positive, but modest, free cash flow.
AI summarized at 10:45 PM ET, 2026-03-29
AI summary scores
INTRADAY: 38 SWING: 63 LONG: 34
Volume vs average
Intraday (cumulative)
−8% (Below avg)
Vol/Avg: 0.92×
RSI
48.36 (Neutral)
Neutral (40–60)
MACD momentum
Intraday
-0.10 (Weak)
MACD: -0.10 Signal: 0.00
Short-Term
+1.31 (Strong)
MACD: -0.98 Signal: -2.30
Long-Term
+0.96 (Strong)
MACD: -3.94 Signal: -4.91
Intraday trend score 30.83

Latest news

AZN 12 articles Positive: 6 Neutral: 5 Negative: 1
Positive GlobeNewswire Inc. • Hutchmed (China) Limited
HUTCHMED Announces SANOVO Trial Demonstrated Significant Progression-Free Survival Benefit of ORPATHYS® Plus TAGRISSO® in Treatment-Naïve Patients with MET-Overexpressing EGFR-mutated Lung Cancer in China

HUTCHMED announced positive Phase III SANOVO trial results showing that ORPATHYS® (savolitinib) combined with TAGRISSO® (osimertinib) demonstrated statistically significant progression-free survival improvements and encouraging overall survival benefits in treatment-naïve patients with MET-overexpressing EGFR-mutated NSCLC in China, extending the clinical value of the combination into the first-line setting.

HCM AZN ORPATHYS® TAGRISSO® SANOVO trial MET overexpression EGFR-mutated NSCLC progression-free survival
Sentiment note

As the co-developer and commercializer of ORPATHYS®, AstraZeneca benefits from positive trial results that validate the therapeutic strength of the combination with its backbone drug TAGRISSO®. The expansion into the first-line setting represents a significant commercial opportunity and strengthens the competitive position of TAGRISSO® in lung cancer treatment.

Neutral The Motley Fool • Reuben Gregg Brewer
Opinion: Bristol Myers Squibb Is a Buy -- but the Real Reason Why Might Surprise Investors

Bristol Myers Squibb faces a significant patent cliff when its cardiovascular drug Eliquis loses protection in 2028, but the company has a strong history of developing replacement drugs. With new products like Camzyos, Opdualag, Breyanzi, and Reblozyl already showing solid results and an impressive pipeline, BMY remains a viable long-term investment at a reasonable 15x P/E ratio and offers a 3.7% dividend yield.

BMY CELGR AZN patent cliff Eliquis pharmaceutical drug pipeline patent expiration
Sentiment note

Mentioned only in context of acquisition rumors that industry watchers consider unlikely. The article explicitly states that focusing on M&A speculation is not a sound long-term investment strategy, so this is treated as peripheral to the main investment thesis.

Positive GlobeNewswire Inc. • Sns Insider
Breast Cancer Therapeutics Market Size to Reach USD 95.14 Billion at a CAGR of 9.20% from 2035 – SNS Insider

The global breast cancer therapeutics market is projected to grow from USD 39.46 billion in 2025 to USD 95.14 billion by 2035, with a CAGR of 9.20%. Growth is driven by increased adoption of targeted therapies, CDK4/6 inhibitors, immunotherapy, and antibody-drug conjugates. North America leads with 38.61% market share, while Asia Pacific shows the fastest growth. Targeted therapy dominates with 64.85% share, while immunotherapy is the fastest-growing segment at 14.25% CAGR.

RHHBY PFE NVS AZN breast cancer therapeutics targeted therapy immunotherapy CDK4/6 inhibitors
Sentiment note

Major pharmaceutical player in oncology with focus on targeted therapies and immunotherapy combinations, well-positioned in the expanding breast cancer therapeutics market.

Neutral Zacks Investment Research • Na
SMMT Rises on Akeso's Win in Phase III Biliary Tract Cancer Study

Summit Therapeutics' partner Akeso announced positive phase III HARMONi-GI1 study results showing ivonescimab plus chemotherapy achieved superior overall survival compared to AstraZeneca's Imfinzi plus chemotherapy in advanced biliary tract cancer patients. The drug also met key secondary endpoints for progression-free survival and objective response rate. These results strengthen ivonescimab's development case beyond its initial NSCLC focus into colorectal and genitourinary cancers.

SMMT AZN MRK ivonescimab biliary tract cancer HARMONi-GI1 overall survival phase III trial
Sentiment note

Imfinzi (durvalumab) was used as the comparator drug in the trial and was outperformed by ivonescimab on primary endpoint. While this represents competitive pressure in the oncology space, it does not directly impact AstraZeneca's existing approvals or revenue streams, and the company has a diversified portfolio.

Positive Zacks Investment Research • Na
Can Eli Lilly's Oncology Portfolio Drive Growth Beyond GLP-1 Drugs?

Eli Lilly's oncology revenues grew 11% to $4.84 billion in H1 2026, with newer drugs like Jaypirca (up 66%) and Inluriyo driving diversification beyond its flagship Verzenio. The company strengthened its blood-cancer pipeline through acquisitions of Ajax Therapeutics and Kelonia. However, Lilly faces intense competition from AstraZeneca, Merck, and Pfizer in the oncology space. The stock trades at a premium valuation (28.03x forward P/E) but holds a Zacks Rank #3 (Hold) rating.

LLY AZN MRK PFE oncology Jaypirca Verzenio Inluriyo
Sentiment note

Strong oncology performance with $14.1B in revenues (up 15% at constant exchange rates) and multiple blockbuster drugs including Tagrisso ($3.8B). Positioned as one of Lilly's strongest competitors.

Positive GlobeNewswire Inc. • Bcc Research
AI Poised to Reshape Blood Cancer Therapeutics as Investment Surges Past $2 Billion Across Leading Biotech and Pharma Players

Artificial intelligence is transforming blood cancer drug discovery and development, with over $2 billion in investment from major biotech and pharma companies. AI is reducing clinical trial timelines by up to 50%, improving patient selection, and enabling next-generation therapies like CAR-T and antibody-drug conjugates. North America leads with 40% of global market share, while Asia-Pacific emerges as a significant growth region.

MRK RHHBY BMY CELGR artificial intelligence blood cancer therapeutics clinical trial acceleration CAR-T cell engineering
Sentiment note

Engaged in generative AI collaboration with Absci for biologics development, demonstrating active investment in AI-enabled drug discovery.

Negative GlobeNewswire Inc. • Hagens Berman
Ionis Pharmaceuticals, Inc. (IONS) Faces Investor Scrutiny After Surprise Trial Failure Drives Stock Down 23% – HBSS

Ionis Pharmaceuticals' stock plunged 23% on July 9, 2026, after its Phase 3 CARDIO-TTRansform trial for eplontersen failed to meet its primary efficacy endpoint. The unexpected failure wiped out $3.3 billion in market capitalization. Hagens Berman has launched an investigation into whether the company was sufficiently transparent about the trial's data and design, potentially violating federal securities laws.

IONS AZN trial failure Phase 3 CARDIO-TTRansform eplontersen ATTR-CM securities investigation stock decline
Sentiment note

As the partner in the failed CARDIO-TTRansform trial, AstraZeneca is negatively impacted by the trial failure, which affects the development prospects of eplontersen and may have implications for the partnership.

Neutral GlobeNewswire Inc. • Ascentage Pharma Group International
Ascentage Pharma Chairman and CEO Dr. Dajun Yang Named to The Medicine Maker Power List 2026

Dr. Dajun Yang, Chairman and CEO of Ascentage Pharma, has been recognized in The Medicine Maker Power List 2026, ranking No. 3 in the Small Molecules category. The recognition highlights the company's achievements in advancing innovative cancer therapies, including the commercialization of olverembatinib and lisaftoclax, with multiple global Phase III clinical trials underway.

TAK AZN MRK PFE oncology small molecule inhibitors BCR-ABL tyrosine kinase inhibitor Bcl-2 inhibitor
Sentiment note

Mentioned as a global partnership partner with Ascentage Pharma, but no specific details about the partnership or its impact are provided in the article.

Positive GlobeNewswire Inc. • Delveinsight
PD-1 and PD-L1 Inhibitors Clinical Trial Pipeline Analysis Demonstrates 180+ Key Companies on the Horizon Expected to Transform the Oncology Space | DelveInsight

A comprehensive analysis reveals over 180 companies developing 200+ PD-1 and PD-L1 inhibitor drugs across various clinical stages. The report highlights major pharmaceutical players advancing pipeline therapies for multiple cancer indications, with approximately 15+ drugs in late-stage development and 30+ in mid and early stages. Recent developments include FDA breakthrough designations and positive clinical trial results for combination therapies.

MRK RHHBY GSK AZN PD-1 inhibitors PD-L1 inhibitors immunotherapy oncology
Sentiment note

AstraZeneca has multiple pipeline candidates including Rilvegostomig in Phase III trials and durvalumab (Infinzi) showing positive results in combination therapies. Recent approval of Datroway (with Daiichi Sankyo) for triple-negative breast cancer demonstrates clinical progress.

Neutral GlobeNewswire Inc. • Researchandmarkets.Com
Clinical Stage Partnering Terms and Agreements in Pharmaceuticals and Biotechnology 2020-2026 | Benchmark More Than 1,800 Biopharma Deals with Various Indexes

ResearchAndMarkets.com released a comprehensive report analyzing over 1,859 clinical-stage pharmaceutical and biotechnology partnership deals announced since 2020. The report provides detailed financial terms, deal structures, contract documents, and insights into negotiation dynamics for clinical-stage drug development collaborations, serving as a benchmarking resource for biopharma dealmakers.

ABBV AMGN AZN GILD clinical-stage partnerships pharmaceutical deals biotechnology collaborations licensing agreements
Sentiment note

Listed among the most active clinical-stage dealmakers featured in the report, but no specific deal outcomes or strategic insights are disclosed.

Neutral GlobeNewswire Inc. • Researchandmarkets.Com
Bioinformatics Collaboration and Licensing Deals 2019-2026 | Compare Upfronts, Milestones, and Royalties for 1,230+ Deals

ResearchAndMarkets.com released a comprehensive report analyzing 1,230+ bioinformatics collaboration and licensing deals from 2019-2026, providing detailed benchmarking of upfronts, milestones, and royalty structures. The report serves as a reference for understanding how partnerships are structured in data-driven and platform-based transactions across the bioinformatics industry.

TXG ILMN RHHBY PFE bioinformatics licensing deals collaboration partnerships
Sentiment note

Included in the list of companies featured in bioinformatics collaboration deals, but lacks specific deal details or strategic insights in the article.

Positive GlobeNewswire Inc. • Sns Insider
Autoimmune Disease Therapeutics Market Size to Reach USD 137.85 Billion by 2035 as Biologics and Precision Medicine Drive Growth | SNS Insider

The global autoimmune disease therapeutics market is projected to grow from USD 80.54 billion in 2025 to USD 137.85 billion by 2035, with a CAGR of 5.52%. Growth is driven by rising prevalence of autoimmune diseases, adoption of biologics, JAK inhibitors, monoclonal antibodies, and precision medicine technologies. North America leads with 39.96% market share, while Asia-Pacific shows the fastest growth at 6.28% CAGR.

ABBV NVS AMGN JNJ autoimmune disease therapeutics biologics JAK inhibitors monoclonal antibodies
Sentiment note

Major pharmaceutical player positioned to benefit from growing autoimmune therapeutics market driven by biologics adoption and precision medicine innovations.

News and sentiment labels describe article tone and are provided for research purposes only. They are not trading recommendations or forecasts.
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